| Michigan Panthers vs. D.C. Defenders | 5-4-2025
Sunday
12:00 PM | Ford Field in Detroit, MI | View Tickets |
| Arlington Renegades vs. Michigan Panthers | 5-10-2025
Saturday
12:00 PM | Choctaw Stadium in Arlington, TX | View Tickets |
| Michigan Wolverines vs. Wisconsin-Milwaukee Panthers | 5-13-2025
Tuesday
4:00 PM | Ray Fisher Stadium in Ann Arbor, MI | View Tickets |
| Houston Roughnecks vs. Michigan Panthers | 5-17-2025
Saturday
12:00 PM | TDECU Stadium in Houston, TX | View Tickets |
| Birmingham Stallions vs. Michigan Panthers | 5-24-2025
Saturday
2:00 PM | Protective Stadium in Birmingham, AL | View Tickets |
| Michigan Panthers vs. Houston Roughnecks | 5-31-2025
Saturday
3:00 PM | Ford Field in Detroit, MI | View Tickets |
| Pittsburgh Panthers Football vs. Central Michigan Chippewas | 9-6-2025
Saturday
TBD | Acrisure Stadium in Pittsburgh, PA | View Tickets |
| Northern Michigan Wildcats Football vs. Davenport University Panthers | 9-20-2025
Saturday
1:00 PM | Superior Dome in Marquette, MI | View Tickets |
| Hillsdale College Chargers Football vs. Kentucky Wesleyan Panthers | 9-27-2025
Saturday
TBD | Frank Waters Stadium in Hillsdale, MI | View Tickets |
| Grand Valley State Lakers Football vs. Davenport University Panthers | 10-4-2025
Saturday
4:00 PM | Lubbers Stadium in Allendale, MI | View Tickets |
| Wayne State Warriors Football vs. Davenport University Panthers | 10-18-2025
Saturday
TBD | Tom Adams Field in Detroit, MI | View Tickets |
| Hillsdale College Chargers Football vs. Ohio Dominican Panthers | 11-15-2025
Saturday
TBD | Frank Waters Stadium in Hillsdale, MI | View Tickets |
